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Anemia

"Gene Therapy for Long-Term Expression of Erythropoietin in Rats."

Published in Blood Weekly, September 25th, 1995

According to the authors' abstract of an article published in Proceedings of the National Academy of Sciences of the United States of America, "The injection of recombinant erythropoietin (Epo) is now widely used for long-term treatment of anemia associated with chronic renal failure, cancer, and human immunodeficiency virus infections. The ability to deliver this hormone by gene therapy rather than by repeated injections could provide substantial clinical and economic benefits. As a preliminary approach. We investigated in rats the expression and biological effects of transplanting autologous vascular smooth muscle cells transduced with a retroviral vector encoding rat Epo cDNA. ...

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