Blood Banking (Viral Inactivation)
"Target Structures for HIV-1 Inactivation by Methylene Blue and Light."
Published in Blood Weekly, November 13th, 1995
According to the authors' abstract of an article published in Journal of Medical Virology, "In a photodynamic virus inactivation procedure for human fresh frozen plasma the plasma is exposed to visible light in the presence of 1 (mu)M methylene blue. This procedure is known to inactivate HIV-1 by at least 10(6.32) TCID50/ml within 10 minutes. To elucidate the mechanism of photodynamic inactivation of HIV-1 by methylene blue/light treatment, reverse transcriptase (RT), the HIV-1 associated protein p24, and viral RNA were examined. In the dark, methylene blue up to 10 (mu)M has no inhibitory effect on recombinant RT. In the presence of light, recombinant RT inactivation was dependent on...
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Source: Blood Weekly (1995-11-13)
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