"Retroviral Vectors for Delivery of IL-12 to the Bone Marrow After Hematopoietic Stem Cell Autografting."

According to an abstract submitted by the authors to the conference entitled Interleukin 12: Cellular and Molecular Immunology of an Important Regulatory Cytokine, held November 9-12, 1995, in New York, New York, "The combination of its ability to induce potent antitumor activity and to promote hematopoiesis suggests potential application of IL-12 as an adjunct to stimulate a graft-versus-leukemia reaction after autologous bone marrow transplantation. Our previous studies in a murine model demonstrated that retrovirally-transduced bone marrow cells can efficiently deliver exogenous IL-12 to the reconstituting hematopoietic system (Stem Cells 12/s1:155, 1994). However, production of...

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