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Transplantation (Bone Marrow)

CD31 Alleles Matching May Reduce GVHD Risk in BMT Recipients

Published in Blood Weekly, March 4th, 1996

Prospective typing of CD31 may lower the risk of acute graft-versus-host disease (GVHD).

The adhesion molecule CD31 is polymorphic, Esther Behar, Ph.D., and colleagues, Stanford University, Stanford, California discovered "Polymorphism of Adhesion Molecule CD31 and Its Role in Acute Graft-Versus-Host Disease," the New England Journal of Medicine, February 1, 1996;334(5):286-291).

Behar et al. reported that they found a polymorphism of CD31 that correlated with results of phenotyping using anti-CD31 monoclonal antibodies and with the occurrence of acute GVHD in recipients of bone marrow transplants.

A frequent, often fatal,...

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