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Tissue Engineering (Cultured Skin)

Cultured Organotype Skin Equivalents Have Potential Gene Therapy Uses

Published in Blood Weekly, March 25th, 1996

Cultured skin equivalents, genetically modified to express therapeutic genes, show potential for use in gene therapy modalities.

Graftskin is a cultured organotypic skin equivalent which has been used in the treatment of various types of wounds. These skin equivalents are comprised of a collagen lattice containing human diploid fibroblasts. When the cultured epidermis is placed at an air-liquefied interface, a keratinizing stratified squamous epithelium forms which is similar to normal human epidermis.

Jeffrey Teumer et al. submitted the results of in vitro and in vivo studies which tested the ability of genetically modified skin equivalents to...

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