"Plasma and Lipids from Stored Blood Cause Acute Lung Injury in an Animal Model."

According to an abstract submitted by the authors at the annual meeting for the Association of American Physicians, American Society for Clinical Investigation, and American Federation for Clinical Research, entitled Biomedicine '96: Medical Research from Bench to Bedside, held May 3-6, 1996, in Washington DC, "Transfusion related acute lung injury (TRALI) is a serious complication of hemotherapy. During blood storage, lipids are generated that prime neutrophils (J Lab Clin Med 1994, 124:684). To investigate the role of these priming agents in TRALI, an isolated, perfused rat lung model was used. Rats were either primed with lipopolysaccharide (LPS) or buffer prior to removal of the...

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