"Autologous Bone Marrow Transplantation (ABMT) in Patients with Follicular Non-Hodgkin's Lymphomas (FNHL) Using CD34⁺ Selection and Retroviral He

According to an abstract submitted by the authors at the annual meeting for the Association of American Physicians, American Society for Clinical Investigation, and American Federation for Clinical Research, entitled Biomedicine '96: Medical Research from Bench to Bedside, held May 3-6, 1996, in Washington DC, "The t(14;18) juxtaposes the bcl-2 oncogene next to the immunoglobulin heavy chain gene enhancer. Dysregulated bcl-2 expression inhibits apoptosis and is central to the pathogenesis of FNHL. The t(14;18) is present in approximately 80% of patients with B-cell FNHL. Studies by Gribben and collaborators indicate that patients undergoing ABMT with grafts that are...

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