AIDS Pathogenesis

Immune Function, Not Viral Features, Determine HIV Pathogenesis

Published in Blood Weekly, May 20th, 1996

New data refute popular hypotheses of AIDS pathogenesis and point to the immune system as the most important means of controlling HIV.

HIV has an extraordinary ability to mutate into new quasispecies within an infected individual. This observation has led many researchers to conclude that the characteristic loss of CD4⁺ T lymphocytes in AIDS occurs when the increasing antigenic diversity of HIV quasispecies overwhelms the immune system (Nowak et al., Science, 1991;254:963).

But extensive study of six individuals - two with rapid CD4 decline, two with slow CD4 decline, and two with stable CD4 counts - shows that it is the stable patients...

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Source: Blood Weekly (1996-05-20)

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