Diagnosis (HCV)

PCR Typing Method Can Identify Specific Genotypes

Published in Blood Weekly, May 20th, 1996

A second-generation method for genotyping hepatitis C virus using polymerase chain reaction (PCR) with core-gene primers allows the distinction between genotypes I/1a and II/1b.

Hepatitis C virus (HCV) genotypes have distinct geographical distributions, and are associated with different degrees of chronic liver disease severity as well as response to interferons.

"In 1992, we reported a genotyping method by PCR with type-specific primers deduced from the core gene, which allows the differentiation of the four common genotypes identified at the time, i.e., I/1a, II/1b, III/2a and IV/2b," researcher Hiroaki Okamoto and colleagues wrote ("A...

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Source: Blood Weekly (1996-05-20)

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