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Parvovirus B19

Virus May Play Role in Acute Chest Syndrome in Sickle Cell Patients

Published in Blood Weekly, May 20th, 1996

Parvovirus B19 may play a role in acute chest syndrome (ACS) in patients with sickle cell disease.

In sickle cell disease patients, ACS is a major cause of morbidity and mortality, accounting for 15 percent of the fatalities in patients with no other concomitant organ dysfunction, noted Elizabeth A. Lowenthal, University of Alabama at Birmingham, Birmingham, Alabama, and colleagues ("Sickle Cell Acute Chest Syndrome Associated with Parvovirus B19 Infection: Case Series and Review," American Journal of Hematology, 1996;51:207-213).

Lowenthal et al. described three cases in which the patients had the hemoglobin SC variant of sickle cell disease and...

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