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Blood Banking (Viral Inactivation)

Rutin Added to Fibrinogen Prevents Degradation during Irradiation

Published in Blood Weekly, May 27th, 1996

Rutin, an antioxidant, can protect fibrinogen during irradiation to inactivate contaminating viruses.

Fibrinogen is susceptible to photochemical degradation during ultraviolet light (UVC) irradiation.

Gerard Marx, Melville Biologics Inc., New York, New York, and colleagues added rutin in a viral inactivation procedure and found that fibrinogen which was irradiated by UVC in the presence of rutin retained its functionality ("Protecting Fibrinogen with Rutin during UVC Irradiation for Viral Inactivation," Photochemistry and Photobiology, April 1996;63(4):541-546).

They also reported that rutin oxidation products are removed during...

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