"Fibroblast Aggregation by Suspension with Conjugates of Poly(Ethylene Glycol) and RGD."

According to the authors' abstract of an article published in Biotechnology and Bioengineering, "Cell aggregates may be useful components of artificial organs and mammalian cell bioreactors, but many cells do not naturally aggregate. In a previous report, we described a method for promoting neural cell aggregation by addition of water-soluble conjugates of cell adhesion peptides, containing the three amino acid sequence Arg-Gly-Asp (RGD), and poly(ethylene glycol) (PEG). Here, we examined the mechanism of conjugate-induced aggregation using fibroblasts and a variety PEG-peptide conjugates. Aggregation was monitored during rotation culture of fibroblasts in the presence of unconjugated...

Want to see the full article?

• Purchase this article for only $3.00