Arthropod Vectors

Dengue Immunization Target: Mosquitoes

Published in Blood Weekly, June 10th, 1996

The best hope for control of dengue viruses may be the intracellular immunization of mosquitoes.

Colorado State University researchers have shown that a genetically engineered Sindbis virus expressing a dengue-targeted antisense molecule blocked the ability of mosquitoes to transmit one of the four strains of dengue virus.

K.E. Olson and colleagues reported their findings in the journal Science ("Genetically Engineered Resistance to Dengue-2 Virus Transmission in Mosquitoes," Science, 1996;272(5263):884-6.)

"This strategy of creating 'intracellular immunity' is the first successful effort to express an exogenous gene that confers...

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Source: Blood Weekly (1996-06-10)

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