"Efficient Ex-Vivo Generation of Functional Dendritic Cells (DCs) Utilizable for Tumor Vaccination from Blood Cell Transplants (BCT) in Cancer Patients."

According to an abstract submitted by the authors to the 32nd Annual Meeting of the American Society of Clinical Oncology, held May 18-21, 1996, in Philadelphia, Pennsylvania, "This study was aimed at the large-scale procurement of functional DCs in a sufficiently practical manner for therapeutic purposes In this perspective, we report that BCTs (n=11) collected by single leukapheresis at the time of CD34⁺ cell mobilization into peripheral blood after 7 g/m² CTX chemotherapy plus cytokines, comprise 140-fold more CD34⁺ progenitors of DCs than a control steady-state BCT. The GM-CSF plus TNF-(alpha) dependent generation of DCs, undistinguishable from skin...

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