Cord Blood
"Detection of Maternal DNA in Placental/Umbilical Cord Blood by Locus-Specific Amplification of the Noninherited Maternal HLA Gene."
Published in Blood Weekly, September 30th, 1996
According to the authors' abstract of an article published in Blood, "A critical issue regarding the broader utilization of placental/umbilical cord blood (PCB) in unrelated bone marrow restoration is the possibility of contamination with maternal lymphocytes capable of immunological reactivity against the eventual recipient. On transplantation, such maternal cells might lead to graft-versus-host disease (GVHD) even if the intended donor's neonatal lymphocytes were unresponsive. We measured the proportion of PCB samples that were contaminated with maternal cells. Placental-maternal sample pairs were selected so that the mother was heterozygous for the DR53 haplotype, whereas the...
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Source: Blood Weekly (1996-09-30)
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