"Nucleotide Sequence Diversity of Hypervariable Region 1 of Hepatitis C Virus in Japanese Hemophiliacs with Chronic Hepatitis C and Patients with Chronic Posttransfuston Hepatitis C."

According to the authors' abstract of an article published in Blood, "Hemophiliac patients with chronic hepatitis C might be exposed to and become infected with multiple hepatitis C virus (HCV) strains by means of frequent use of blood products, even if they are infected with a single subtype of HCV. To test this hypothesis, we analyzed the genetic diversity of hypervariable region 1 (HVR1) of HCV in chronically infected hemophiliacs and in patients with chronic posttransfusion hepatitis with a single HCV inoculation. The diversity of nucleotide sequences in HVR1 of serum HCV RNA was compared between 21 hemophiliacs infected with a single HCV subtype and 16 patients with posttransfusion...

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