Transfusion (Platelet Concentrates)

Preparation Method Caused Severe Febrile Reactions

Published in Blood Weekly, November 25th, 1996

Less febrile reactions were associated with transfusions of white blood cell (WBC)-reduced platelet concentrates (PCs) prepared by the buffy coat method, compared to the platelet-rich plasma method.

A relation between febrile reactions to platelet transfusion and high cytokine levels in PC had been found previously. Levels of cytokines, such as IL-6 related to the WBC content of PCs during storage, and the early removal of WBC, should avert such reactions, noted L. Muylle and colleagues ("Febrile Reactions to Platelet Transfusion: the Effect of Increased Interleukin 6 Levels in Concentrates Prepared by the Platelet-Rich Plasma Method," Transfusion,...

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Source: Blood Weekly (1996-11-25)

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