"Comparison of a Weekly Versus Daily Perioperative Dosing Regimen of Epoetin Alfa on Transfusion Requirements in Patients Undergoing Major Elective Surgery."

According to an abstract submitted by the authors to the 38th Annual Meeting of the American Society of Hematology, held December 6-10, 1996, in Orlando, Florida, "Previous studies have demonstrated the efficacy of a daily regimen of perioperative Epoetin alfa in reducing allogeneic transfusion in patients with a prestudy hemoglobin (Hb) >10 to {{<=}}13 g/dL. Recent data demonstrate that earlier and less frequent dosing may be safe, convenient, and reduce total drug cost. A multicenter, randomized, open-label, parallel-group study compared the safety and efficacy of two Epoetin alfa dosing regimens (600 IU/kg once weekly for 3 weeks prior to surgery and on the day of surgery, and...

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