"The Toxicities of Native and Modified Hemoglobins."

According to the authors' abstract of an article published in Free Radical Biology and Medicine, "Recent research on the potential use of hemoglobin derivatives as a blood substitute has revealed that the administration of large quantities of free hemoglobin into the circulation results in a variety of toxic side effects. Because it has been well established that hemoglobin, like myoglobin, has considerable pro-oxidant activity, a number of studies have appeared suggesting that the administered hemoglobins may catalyze various oxidative and peroxidative reactions, which in turn, would cause the observed pathologic conditions. This occurs as a result of the in vivo formation of highly...

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