"Serum Cortisol/DHEA Ratio During HIV Infection."

According to an abstract submitted by the authors to the Ninth Symposium on HIV Infection entitled From Virology ... To Therapy, held March 6-8, 1997, in Toulon, France, "The progression of HIV infection is accompanied by a severe immunodepression due predominantly to the selective depletion of CD4 lymphocytes, particularly during advanced stages. The adrenal steroid hormones, especially cortisol and DHEA, modulate the immune system. Cortisol decreases T-cell proliferation and function, inhibiting the production of cytokines. The adrenal androgen DHEA stimulates helper T-cell function, enhancing the capacity of activated T cells to produce interleukin-2, and counteract inhibition of...

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