"Photosensitized Decontamination of Blood with the Silicon Phthalocyanine Pc 4: No Activation of the Human Immunodeficiency Virus Promoter."

According to the authors' abstract of an article published in Photochemistry and Photobiology, "Photochemical decontamination of red blood cell concentrates (RBCC) with the silicon phthalocyanine Pc4 and red light is being studied to enhance the viral safety of blood transfusion. Recent reports indicate that treatments with radiation and various phototsensitizing agents can activate the promoter of human immunodeficiency virus (HIV). This raises the possibility that an inadequate, sublethal photochemical treatment of RBCC could induce HIV in latently infected cells. This question has been addressed using HeLa cells stably transfected with the chloramphenicol acetyl transferase gene...

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