Blood Substitutes

LEH Modulates Inflammatory Response of Cells

Published in Blood Weekly, June 9th, 1997

Liposome-encapsulated hemoglobin (LEH) can modulate production of tumor necrosis factor-(alpha) (TNF-(alpha)) from mononuclear phagocytes.

This may be performed through a posttranscriptional effect, said Alan S. Rudolph, Ph.D., Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, D.C., and colleagues ("Liposome-Encapsulated Hemoglobin Modulates Lipopolysaccharide-Induced tumor Necrosis Factor-alpha Production in Mice," Critical Care Medicine, 1997;25:460-468).

"Phagocytosis of liposome-encapsulated hemoglobin by macrophages, and binding of lipopolysaccharide to the outer surface of liposome-encapsulated hemoglobin,...

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Source: Blood Weekly (1997-06-09)

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