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AIDS Therapies

Passive Immunization Yields High Levels of Anti-HIV Antibody

Published in Blood Weekly, September 8th, 1997

AIDS patients who receive passive immunization with hyperimmune anti-HIV immunoglobulin achieve serum titers of anti-HIV antibodies similar to those that neutralize the virus in laboratory cultures.

The finding comes from a clinical trial of HIVIG, the commercial HIV hyperimmune serum preparation manufactured by North American Biologicals, Boca Raton, Florida.

"This study indicates that high titers of anti-p24 antibody can be maintained with a monthly administration schedule of HIVIG and that short-term safety is acceptable," wrote University of Minnesota researcher Courtney V. Fletcher and colleagues. "Comparisons to evaluate the therapeutic...

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