Published in Blood Weekly, September 8th, 1997
DNA amplification by polymerase chain reaction (PCR) has the potential to reduce the time taken for the direct identification of Mycobacterium tuberculosis complex and M. avium-M. intracellulare complex (MAC) by allowing the use of diverse genetic elements as target sequences. Problems still exist, however, including the presence of inhibitors of the PCR which may cause false-negative results (Clarridge et al., J Clin Microbiol 1993;31:2049-2056).
The isolation of small amounts of DNA...
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