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Sickle Cell Disease

Nitric Oxide Gas May Treat, Prevent Sickle Cell Crisis

Published in Blood Weekly, September 15th, 1997

A study by researchers at the Massachusetts General Hospital (MGH) and other Boston hospitals suggests that inhaled nitric oxide gas might successfully treat sickle cell disease and its characteristic episodes of debilitating pain, called sickle cell crisis.

Described in a report in the September 1997 Journal of Clinical Investigation, the approach would attack directly the abnormal "sickle" hemoglobin that causes sickle cell crisis, a condition that currently can be treated only with pain-killing drugs. If follow-up studies prove successful, patients might someday treat or prevent sickle cell crisis symptoms by self-administering nitric oxide with inhalers similar...

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