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Blood Substitutes

"In vitro Effects of a Novel Hemoglobin-Based Oxygen Carrier on Routine Chemistry, Therapeutic Drug, Coagulation, Hematology, and Blood Bank Assays."

Published in Blood Weekly, October 27th, 1997

According to the authors' abstract of an article published in Clinical Chemistry, "Red blood cell (RBC) replacement solutions are being developed as alternatives to allogeneic RBC use in blood transfusions in the treatment of massive trauma, to achieve hemodynamic stability during elective surgery, and to increase oxygen-carrying capacity in anemia. Hemoglobin-based oxygen carrier (HBOC)-201 (Biopure Corp.) is a purified, sterile, isosmotic glutaraldehyde-polymerized bovine hemoglobin. Because this product is acellular, blood components containing this substance appear hemolyzed. This study reports on the interferences produced by the presence of HBOC-201 in a variety of clinical...

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