Transplantation (Organ Rejection)

Gene Therapy Prevents Transplant Failure Complication In Animal Model

Published in Blood Weekly, November 3rd, 1997

A study by researchers at the University of Pittsburgh Medical Center may lead to the use of gene therapy for the prevention of chronic organ rejection, a major cause of patient death following transplantation.

The study, published in the October 1997 issue of The Journal of Clinical Investigation, found that transplant arteriosclerosis, a potentially fatal complication of transplantation, can be prevented by the enzyme iNOS (inducible nitric oxide synthase) in animals receiving aortic grafts.

iNOS is an enzyme that triggers production of nitric oxide (NO), a potent chemical that suppresses transplant arteriosclerosis, which occurs over several...

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Source: Blood Weekly (1997-11-03)

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