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Cytomegalovirus

"Spread of Human Cytomegalovirus (HCMV) after Infection of Human Hematopoietic Progenitor Cells: Model of HCMV Latency."

Published in Blood Weekly, November 10th, 1997

According to the authors' abstract of an article published in Blood, "Clinical experience and laboratory data suggest that human cytomegalovirus (HCMV) is present in peripheral blood of seropositive individuals in a latent or persistent state and can be transmitted via blood products and be reactivated in seropositive imunocompromised patients. The pathophysiology of HCMV latency and the nature of HCMV interaction with hematopoietic cells remains unknown. In this study, we investigated the infection of bone marrow (BM) progenitor cells and their progeny as a model of HCMV latency. A clinical isolate and the recombinant laboratory strain Towne/lox containing the Escherichia coli...

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