"Combination Immunotherapy Which Neutralises the Effects of TNF alpha and IL-1 beta Attenuates the Circulatory Failure and Multiple Organ Dysfunction Caused by Endotoxin in the Rat."

According to the authors' abstract of an article published in Journal of Physiology and Pharmacology, "Pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF alpha) or interleukin-1 beta (IL-1 beta) are implicated in the pathogenesis of septic shock. Here we investigate the role of endogenous TNF alpha and IL-1 beta on (i) the circulatory failure, (ii) the multiple organ dysfunction syndrome (MODS) and (iii) the induction of the inducible isoform of nitric oxide (NO) synthase (iNOS) caused by endotoxin (LPS) in the anaesthetised rat. Here we demonstrate that (i) a polyclonal antibody against TNF alpha, (ii) a polyclonal antibody against IL-1, (iii) co-administration of...

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