Blood Substitutes
"DCLHb, a Well-Characterized Hemoglobin."
Published in Blood Weekly, April 6th, 1998
According to an abstract submitted by the authors to the 7th International Symposium on Blood Substitutes (7-ISBS), held September 7-10, 1997, in Tokyo, Japan, "Diaspirin crosslinked hemoglobin (DCLHb), a hemoglobin-based oxygen carrier having therapeutic potential, is in Phase III clinical trials. DCLHb is an intramolecularly crosslinked human hemoglobin in which a fumaryl bridge covalently links the lysine 99 residues of the (alpha)-subunits. We have investigated the effect of crosslinking on the structure and function of DCLHb in comparison to human hemoglobin. The oxygen affinity and high degree of cooperativity of oxygen binding exhibited by DCLHb were similar to the corresponding...
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Source: Blood Weekly (1998-04-06)
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