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Polycythemia Vera

Molecular Defect Test for PV Could Be Malignancy Model

Published in Blood Weekly, April 13th, 1998

A potential definitive test for polycythemia vera, a malignant blood disorder, may serve as a model for identifying the origins of malignant disease.

Polycythemia vera (PV) is marked by a great increase in the number of red cells in the blood, resulting in headaches and potentially fatal blood clots. It usually is treated by a modern form of bloodletting, although more severe cases may require chemotherapy.

A unique molecular defect in the unusual blood disorder, first identified and described at Johns Hopkins by the late Sir William Osler almost a century ago, has been discovered by a team of his professional descendants. The molecular defect that...

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