Bone Marrow Transplantation

GVHD and Prevention of Rejection May Be Separable Effects

Published in Blood Weekly, July 27th, 1998

Graft-versus-host disease and prevention of graft rejection may be mediated by different populations of donor T cells.

In allogeneic bone marrow transplantation, donor T cells that recognize recipient alloantigens prevent rejection, but they also are responsible for causing graft-versus-host disease (GVHD).

To determine whether the ability to prevent bone marrow graft rejection could be separated from the ability to cause GVHD, Yoichiro Kusunoki, of the Fred Hutchinson Cancer Research Center, and colleagues generated a panel of four different CD8 cytotoxic T-lymphocyte clones specific for H2^d alloantigens ("Prevention of Marrow Graft...

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Source: Blood Weekly (1998-07-27)

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