Published in Blood Weekly, September 7th, 1998
Viral genetic factors that determine in vivo reactivation efficiencies of fully replication competent wild-type HSV strains have not been identified, noted N.M. Sawtell, Children's Hospital Medical Center, Cincinnati, Ohio, and colleagues.
A common laboratory strain, KOS reactivates in vivo at lower efficiencies than either strain 17syn+ or strain McKrae (Strelow et al., J Gen Virol, 1994;75:2475-2480 and others).
"An important first step in understanding the molecular basis for this observation is...
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