Conference Coverage (12th World AIDS)
Early HAART May Prevent CTL Exhaustion
Published in Blood Weekly, September 21st, 1998
Hugo Soudeyns of Beaumont Hospital, Lausanne, Switzerland, and colleagues analyzed cytotoxic T-lymphocyte (CTL) subsets in 24 patients with primary HIV infection.
The 11 patients who received no treatment had a massive expansion of virtually all CTL subsets as defined by the T-cell receptor beta chains (V(beta)). But nine patients treated with highly active antiretroviral therapy (HAART) had rapid stabilization of V(beta) subsets.
"A global mobilization of the CD8 subtypes occurs in primary HIV infection, and HAART...
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Source: Blood Weekly (1998-09-21)
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