Hematopoietic Gene Transfer

Ex Vivo Expansion Diminishes Long-Term Repopulating Ability of Stem Cells

Published in Blood Weekly, September 28th, 1998

Ex vivo expansion of genetically marked hematopoietic stem cells (HSCs) resulted in diminished long-term repopulating ability after transplantation.

The possibility of ex vivo expansion of primitive hematopoietic cells is of considerable interest for both gene therapy and transplantation applications. Unfortunately, early preclinical and clinical studies of transduced hematopoietic progenitor cells have resulted in levels of engraftment of the genetically altered cells that were too low to be of clinical benefit (C.E. Dunbar et al., Curr Opin Hematol, 1996;3:430).

J.F. Tisdale and colleagues from the National Institutes of Health, Maryland, sought...

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Source: Blood Weekly (1998-09-28)

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