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Creutzfeldt-Jakob Disease

Very Low Infectivity Detected in Plasma

Published in Blood Weekly, September 28th, 1998

The administration of human plasma protein concentrates poses a potential, but minimal, risk of acquiring Creutzfeldt-Jakob disease, NIH researchers reported.

The administration of blood components from donors who later developed Creutzfeldt-Jakob disease (CJD), a transmissible spongiform encephalopathy (TSE), has raised concern that CJD may be transmitted via blood or blood components. Blood of experimentally infected animals, and of humans with CJD, sometimes contained low levels of the infectious agent (Brown, Curr Opin Hematol, 1995;2:472-477).

Paul Brown, National Institutes of Health (NIH), and colleagues studied the distribution of blood...

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