Plasmodium falciparum Malaria

Promiscuous Epitope in Pfg27 May Have Role in Design of Vaccine

Published in Blood Weekly, October 12th, 1998

Recently identified T-cell epitopes may be able to block Plasmodium falciparum gametocyte infectivity.

Building on their earlier research focusing on immunity against P. falciparum sexual stages, also known as malaria transmission-blocking immunity (TBI), Carmen E. Contreras, Johns Hopkins University, and colleagues performed studies to better understand human T-cell responses against epitopes in the 27-kDa gametocyte protein (Pfg27) ("Mapping of Specific and Promiscuous HLA-DR-Restricted T-Cell Epitopes on the Plasmodium falciparum 27-Kilodalton Sexual Stage-Specific Antigen," Infection and Immunity, 1998;66:3579-3590).

Pfg27 is...

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Source: Blood Weekly (1998-10-12)

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