"Effect of alpha alpha-Cross-Linked Hemoglobin and Pyridoxalated Hemoglobin Polyoxyethylene Conjugate Solutions on Gastrointestinal Regional Perfusion in Hemorrhagic Shock."

According to the authors' abstract of an article published in Journal of Trauma - Injury Infection and Critical Care, "Background: Hemoglobin-based blood substitutes may cause vasoconstriction, which could limit organ perfusion during trauma resuscitation. We investigated the effect of two hemoglobin solutions on regional blood flow and mucosal perfusion in the gastrointestinal tract in a hemorrhagic shock model. Methods: Twenty-four swine were bled 30% of blood volume over 1 hour. Six additional animals were anesthetized and monitored but did not undergo hemorrhage. Bled animals were resuscitated with alpha alpha-hemoglobin (alpha alpha Hb), pyridoxalated hemoglobin...

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