Liver Transplantation

Kinetic Model of Circulatory Regulation of t-PA Reported

Published in Blood Weekly, November 30th, 1998

Anhepatic fibrinolytic activity in liver transplantation was a function of both operative blood loss and the preoperative fibrinolytic state, researchers reported.

Tissue plasminogen activator (t-PA) is cleared almost exclusively by the liver (t##1/2##=2-4 min.). During the anhepatic stage of liver transplantation, hepatic clearance is eliminated and t-PA levels should rise rapidly; however, this does not always take place, noted K.P. Crookston and colleagues, University of Washington, Seattle, Washington.

Crookston et al. developed computer simulations of the circulatory regulation of t-PA secretion, inhibition, and clearance during...

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Source: Blood Weekly (1998-11-30)

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