Lyme Disease

DbpA Is Target for Protective Antibodies

Published in Blood Weekly, February 1st, 1999

DbpA is expressed by Borrelia burgdorferi and is a target for antibodies, researchers report.

DbpA is a target for antibodies that protect mice against infection by cultured B. burgdorferi. Infected mice show early and sustained humoral responses to both DbpA and DbpB; this suggests that these proteins are expressed in vivo.

Many antigens expressed in mammals by B. burgdorferi are repressed in vitro at lower growth temperatures. These observations have been extended to include DbpA and DbpB, indicated David R. Cassatt and colleagues.

David R. Cassatt et al. performed a study to confirm that the protective...

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Source: Blood Weekly (1999-02-01)

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