Viral Inactivation

MB-Treated Plasma May Have Clinical Applications

Published in Blood Weekly, February 15th, 1999

Plasma treated by methylene blue photoinactivation might be suitable for in vitro resuspension and storage of platelets or red cells.

This is because of the lack of influence of methylene blue-treated plasma on various in vitro platelet and red cell assays, reported Peter L. Perrotta, Yale University School of Medicine, New Haven, Connecticut, and colleagues ("Effects of Methylene Blue-Treated Plasma on Red Cells and Stored Platelet Concentrates," Transfusion, 1999;39(1):63-69).

Photochemical methods are known to effectively inactivate extracellular viruses and bacteria in blood components. The treatment of plasma with methylene blue (MB), a...

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Source: Blood Weekly (1999-02-15)

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