Published in Blood Weekly, March 8th, 1999
The term "prion" means "infectious protein." This concept arose from studies of the mammalian transmissible spongiform encephalopathies (TSEs) (Alper et al., Nature, 1967:214:764-766; Griffith, Nature, 1967;215:1043-1044).
The [URE3] nonchromosomal genetic element is a prion of Ure2p, a regulator of nitrogen catabolism in the yeast Saccharomyces cerevisiae. Ure2p1-65 is the prion domain of Ure2p, sufficient to propagate [URE3] in vivo, indicated U.S. National Institutes of Health researcher Herman K. Edskes and colleagues ("The [URE3] Prion Is An Aggregated Form of Ure2p That Can...
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