Allograft Tolerance

Recombinant Interferon Provides B Cell Help

Published in Blood Weekly, March 8th, 1999

Recombinant interferon-gamma restored anti-donor humoral response in donor-specific blood transfusion-treated recipient animals.

R. Josein and colleagues induced donor-specific tolerance to heart allograft in adult Lewis rats by pregraft donor-specific blood transfusion (DST) ("Recombinant IFN-gamma Abrogates Allograft Tolerance Induced by Donor-Specific Blood Transfusion by Restoring Alloantibody Production," European Journal of Immunology, January 1999;29(1):317-326).

Previously, they demonstrated that this tolerant state is characterized by a dramatic inhibition of T cell and macrophage activation. Additionally, tolerant animals could not mount...

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Source: Blood Weekly (1999-03-08)

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