Blood Substitutes (Animal Models)
"Microvascular Responses to Hemodilution With Hb Vesicles as Red Blood Cell Substitutes: Influence of O-2 Affinity."
Published in Blood Weekly, March 15th, 1999
According to the authors' abstract of an article published in American Journal of Physiology - Heart and Circulatory Physiology, "Phospholipid vesicles encapsulating purified hemoglobin (HbV) were developed to provide O-2-carrying capacity to plasma expanders. Microvascular perfusion was determined for HbV with different O-2 affinity (P-50 = 9, 16, and 30 mmHg) prepared by co-encapsulating pyridoxal 5'-phosphate (PLP) at the molar ratios of[PLP]/[Hb] = 0, 0.5, and 3, respectively (cf. hamster blood, P-50: 28 mmHg), and suspended in 8 g/dl human serum albumin (HSA). Eighty percent of the red blood cell (RBC) mass of conscious Syrian golden hamsters fitted with dorsal skinfold windows was...
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Source: Blood Weekly (1999-03-15)
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