Human Albumin

Use of Sterile Water Alone for Dilution Is Very Dangerous

Published in Blood Weekly, March 29th, 1999

Using sterile water to dilute human albumin may cause life threatening conditions.

Since 1994, the U.S. Food and Drug Administration (FDA) has received 10 reports of hemolysis associated with the infusion of 25 percent human albumin diluted with sterile water. One of the patients died.

Since 1994 there has been a shortage of 5 percent human albumin in the United States. The product is used off-label during therapeutic plasma exchange (TPE).

Because of the shortage, hospital pharmacists may prepare 5 percent solution of human albumin by diluting 25 percent albumin with 0.9 percent NaCl or 5 percent dextrose. If sterile water...

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Source: Blood Weekly (1999-03-29)

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