Animal Models
"Rhesus Macaque as an Animal Model for Hemophilia B Gene Therapy."
Published in Blood Weekly, April 26th, 1999
According to the authors' abstract of an article published in Blood, "We have determined the 2905 nucleotide sequence of the rhesus macaque factor IX complementary DNA (cDNA) and found it to be greater than 95% identical to that of the human factor IX cDNA. The cDNA has a large 3' untranslated region like the human cDNA, but unlike the human cDNA has two polyadenylation sites 224 nucleotides apart that are used for transcription of the messenger RNA. The deduced amino acid sequence is greater than 97% identical to that of human factor IX, differing in only 11 of 461 amino acids in the complete precursor protein. We found a single silent polymorphism in the nucleotide sequence at the...
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Source: Blood Weekly (1999-04-26)
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