Published in Blood Weekly, May 17th, 1999
Allogeneic bone marrow transplantation (allo-BMT) is associated with both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect.
Nobuhiro Tsukada of Japan's Niigata University School of Medicine and colleagues studied the contribution of cytotoxic effector mechanisms, which are mediated by tumor necrosis factor-(alpha) (TNF-(alpha)), Fas ligand (FasL), or perforin, to GVHD and GVL effect in a murine BMT model ("Graft-Versus-Leukemia Effect and...
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