Hematopoiesis

Mechanism of flt3 Ligand Expression in Bone Marrow Failure

Published in Blood Weekly, May 17th, 1999

Increased levels of flt3 ligand in bone marrow failure are due to the mobilization of preformed flt3 ligand from intracellular stores, study findings indicate.

The flt3 ligand (FL) is a growth factor for primitive hematopoietic cells. Serum levels of FL are inversely related to the number and proliferative capacity of early hematopoietic progenitors.

Elena Chklovskaia, University Hospital Basel, Switzerland, and colleagues performed a study to elucidate the molecular mechanism underlying this regulation ("Mechanism of flt3 Ligand Expression in Bone Marrow Failure: Translocation From Intracellular Stores to the Surface of T Lymphocytes After...

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Source: Blood Weekly (1999-05-17)

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