AIDS Vaccines

HIV Immunotypes Cross Clade Barriers

Published in Blood Weekly, May 24th, 1999

Based on the immunochemical reactivities of their outer envelopes, HIV-1 strains cluster into seven immunotypes.

These immunotypes - each distinguished by unique signature peptide sequences - are different from the familiar genotypic classification of HIV-1 into subtypes or clades.

"There is every reason to believe that an appropriately constructed and delivered polyvalent HIV vaccine will induce a broad protective response," wrote Susan Zolla-Pazner of Veteran's Affairs Medical Center, New York, and colleagues.

"To construct such a vaccine, it is critical to understand, as completely as possible, the antigenic structure of HIV,...

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Source: Blood Weekly (1999-05-24)

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