Chagas' Disease

Platelet-Activating Factor Coordinates Resistance to Infection

Published in Blood Weekly, July 12th, 1999

Platelet-activating factor is produced during Trypanosoma cruzi infection and is involved in mediating resistance to infection, study findings suggest.

Infection with the protozoan flagellate T. cruzi causes Chagas' disease, a major public health problem in many Latin American countries.

T. cruzi replicates in nucleated cells and is susceptible to being killed by gamma interferon-activated macrophages through a mechanism dependent upon nitric oxide (NO) biosynthesis.

Julio C.S. Aliberti of Brazil's University of Sao Paulo and colleagues investigated the role of platelet-activating factor (PAF) in the induction...

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Source: Blood Weekly (1999-07-12)

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